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JWH-051
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It has similar effects to other cannabinoid agonists such as sedation and analgesia, but with a relatively strong antiinflammatory effect due to its strong activity at CB2.

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SKU: N/A Category: Synthetic Cannabinoids Tags: Buy JWH-051 Online, JWH-051 For Sale, Order JWH-051 Online, Where to buy JWH-051 Online
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Description

JWH-051 is an analgesic drug which is a cannabinoid agonist. Its chemical structure is closely related to that of the potent cannabinoid agonist HU-210, with the only difference being the removal of the hydroxyl group at position 1 of the aromatic ring.

It was discovered and named after John W. Huffman.

JWH-051 retains high affinity for the CB1 receptor,

but is a much stronger agonist for CB2, with a Ki value of 14nM at CB2 vs 19nM at CB1.

It was one of the first CB2-selective ligands developed,

although its selectivity for CB2 is modest compared to newer compounds such as HU-308.

Buy JWH-051

JWH-051

JWH-051 is an analgesic drug which is a cannabinoid agonist.

Its chemical structure is closely related to that of the potent cannabinoid agonist HU-210,

with the only difference being the removal of the hydroxyl group at position 1 of the aromatic ring.

It was discovered and named after John W. Huffman.

JWH-051 retains high affinity for the CB1 receptor, but is a much stronger agonist for CB2, with a Ki value of 14nM at CB2 vs 19nM at CB1.

It was one of the first CB2-selective ligands developed, although its selectivity for CB2 is modest compared to newer compounds such as HU-308.

It has similar effects to other cannabinoid agonists such as sedation and analgesia,

but with a relatively strong antiinflammatory effect due to its strong activity at CB2

Cannabinoid Receptor 2 Agonist JWH-015 Inhibits Interleukin-1β-Induced Inflammation in Rheumatoid Arthritis Synovial Fibroblasts and in Adjuvant Induced Arthritis Rat via Glucocorticoid Receptor

Management of pain in the treatment of rheumatoid arthritis (RA) is a priority that is not fully addressed by the conventional therapies.

In the present study, we evaluated the efficacy of cannabinoid receptor 2 (CB2) agonist

JWH-015 using RA synovial fibroblasts (RASFs) obtained from

patients diagnosed with RA and in a rat adjuvant-induced arthritis (AIA) model of RA.

Pretreatment of human RASFs with JWH-015 (10–20 μM) markedly

inhibited the ability of pro-inflammatory cytokine interleukin-1β (IL-1β)

to induce production of IL-6 and IL-8 and

cellular expression of inflammatory cyclooxygenase-2 (COX-2).

JWH-015 was effective in reducing IL-1β-induced phosphorylation of TAK1 (Thr184/187) and

JNK/SAPK in human RASFs. While the knockdown of CB2 in RASFs using siRNA method reduced IL-1β-induced inflammation

 

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100grams, 10grams, 1gram, 1Kg, 25grams, 2grams, 5 grams, 500grams, 50grams

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