A synthetic cannabinoid found in several versions of the herbal mixture “Spice,” JWH-073 is considerably more potent than natural THC from cannabis and has an extended duration of action. Illicit use centers on its psychoactive effects which mimic those of Δ⁹-THC. This synthetic cannabinoid presents significant challenges for detection by typical Δ⁹-THC testing assays. Since the US Drug Enforcement Agency (DEA) listed JWH-073 on its Drugs and Chemicals of Concern list in July, 2009, federal authorities have reported seizures of Spice in Ohio, Pennsylvania, and Florida. Several states have passed legislative action restricting the sale or possession of JWH-073 including Alabama, Arkansas, Kansas, Kentucky, Louisiana, Missouri, and Tennessee.