BEST PURITY JWH-018 FOR SALE
Full Chemical Name: JWH-018
Systematic IUPAC Name Naphthalen-1-yl-(1-pentylindol-3-yl)methanone
CAS Number 209414-07-3
Best purity Jwh-018 for sale
ChemSpider Number 8558143
Molecular Formula C24H23NO
Molecular Mass 341.45 g/mol
WHAT IS JWH 018?
JWH-018 (1-pentyl-3-(1-naphthoyl)indole) or AM-678 is an analgesic chemical from the naphthoylindole family that acts as a full agonist at both the CB1 and CB2
cannabinoid receptors, with some selectivity for CB2.
It produces effects in animals similar to those of tetrahydrocannabinol (THC), a cannabinoid naturally present in cannabis, leading to its use in synthetic
cannabis products that in some countries are sold legally as “incense blends”.
As a full agonist at both the CB1 and CB2 cannabinoid receptors, this chemical compound is classified as an analgesic medication.
The analgesic effects of cannabinoid ligands, mediated by CB1 receptors are well established in treatment of neuropathic pain, as well as cancer pain and arthritis.
These compounds work by mimicking the body’s naturally-produced endocannabinoid hormones such as 2-AG and anandamide (AEA), which are biologically active and
can exacerbate or inhibit nerve signaling.
As the cause is poorly understood in chronic pain states, more research and
development must be done before the therapeutic potential of this class of biologic compounds can be realized
JWH 018 is a mildly selective agonist of the peripheral cannabinoid (CB2) receptor, derived from the
aminoalkylindole WIN 55,212-2. The Ki values for binding central cannabinoid (CB1) and CB2 receptors are 9.0 and
2.94 nM, respectively, for a CB1:CB2 ratio of 3.06.1 Its effects on suppression of spontaneous activity, maximum
possible antinociceptive effect in the tail-flick assay, and rectal temperature are comparable to those of WIN 55,212-2
when tested in rats. buy Jwh-018
Jwh-018 for sale
the JWH group is a synthetic cannabinoid with analgesic effects.Its full chemical name is 4-methoxynaphthalen- 1-
yl- (1-pentylindol- 3-yl)methanone with chemical formula as C25H25NO2 and molecular mass 371.47 g/mol..